Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis
نویسندگان
چکیده
منابع مشابه
gm-csf differentially regulates eosinophil and neutrophil adhesive interactions with vascular endothelium in vivo
allergic airway inflammation is characterized by elaboration of cytokines and chemokines leading to recruitment of inflammatory leukocytes, predominantly eosinophils, to the airways. granulocyte macrophage colony stimulating factor (gm-csf) is generated in the lungs of human subjects with asthma in response to allergen challenge and is necessary for the development of allergen-induced bronchial...
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Pre-incubation of human neutrophils with pertussis toxin significantly inhibited the neutrophil-directed biologic actions of granulocyte-macrophage colony-stimulating factor (GM-CSF) in three separate assays: the induction of c-fos mRNA, the enhancement of both platelet-activating factor-induced mobilization of intracellular calcium, and stimulation of leukotriene synthesis by the calcium ionop...
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Granulocyte macrophage-colony stimulating factor (GM-CSF) has immuno-stimulatory effects. We hypothesized that GM-CSF plays an important role both in lipopolysaccharide (LPS)- and hemorrhage-induced acute lung injury (ALI). We also postulated that GM-CSF augments LPS-induced inflammation by priming neutrophils. ALI was induced in GM-CSF-/- or control C57BL mice either by LPS injection or by hem...
متن کاملGM-CSF differentially regulates eosinophil and neutrophil adhesive interactions with vascular endothelium in vivo.
Allergic airway inflammation is characterized by elaboration of cytokines and chemokines leading to recruitment of inflammatory leukocytes, predominantly eosinophils, to the airways. Granulocyte macrophage colony stimulating factor (GM-CSF) is generated in the lungs of human subjects with asthma in response to allergen challenge and is necessary for the development of allergen-induced bronchial...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2016
ISSN: 0741-5400,1938-3673
DOI: 10.1189/jlb.3ab0416-189rr